Originally, Symbiotes were naturally weakened by intense sounds and intense heat especially large fires. And in some stories and games, (mostly mentioned in the 2000 Spider-Man game), they are also weakened by saw-dust. However as each new symbiote has spawned a child, a natural evolution seems to not only increase their strengths, but also reduce their weaknesses. Still, there has not been an invulnerable symbiote in mainstream continuity as even the newest breeds can still be harmed by incredible amounts of sonic waves and heat. Also in the mainstream Marvel Universe, symbiotes are invulnerable to the heat produced by high voltage electricity.
In some incarnations, the symbiote is depicted as requiring a certain chemical (most likely phenethylamine) to stay sane and healthy, which has been said to be found abundantly in two sources: chocolate and human brain tissue. Thus the host is forced to steal/purchase large amounts of chocolate or become an unwilling cannibal who devours the brains of those he kills. This peculiar trait has only been witnessed in the Venom symbiote, however, both Carnage and Toxin have threatened their enemies with aspirations to "eating their brains", as well as various other body parts. Some symbiotes have no weaknesses.
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